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KMID : 0360120100320010009
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Journal of the Korean Society of Maxillofacial Plastic Reconstructive Surgeons
2010 Volume.32 No. 1 p.9 ~ p.15
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Bone Regeneration with Injectable MPEG-PCL Diblock Copolymer and Bone Marrow Mesenchymal Stem Cell
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Jeong You-Min
Lee Tai-Hyung
Park Jeong-Kyun
Kim Won-Suk
Shin Joo-Hee
Lee Eui-Seok
Rim Jae-Suk
Jang Hyon-Seok
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Abstract
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Aim of the study: As an injectable scaffold, MPEG-PCL diblock copolymer was applied in bone tissue engineering. In vivo bone formation was evaluated by soft X-ray, histology based on the rat calvarial critical size defect model.
Materials and Methods: New bone formation was evaluated with MPEG-PCL diblock copolymer in rat calvarial critical size bone defect. No graft was served as control. 4, 8 weeks after implantation, gross evidence of bone regeneration was evaluated by histology and soft X-ray analysis.
Results: The improved and effective bone regeneration was achieved with the BMP-2 and osteoblasts loaded MPEG-PCL diblock copolymer.
Conclusion: It was confirmed that MPEG-PCL temperature sensitive hydrogels was useful as an injectable scaffold in bone regeneration.
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KEYWORD
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Injectable scaffold, MPEG-PCL diblock copolymer, Bone tissue engineering, BMP-2, Osteoblasts
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